Dr. Huang has a long-standing interest in in vivo imaging of biological processes. He has profound knowledge on Nanobody-based probe development for imaging cell surface markers in vitro and in vivo. His current focus is on using advanced imaging technologies to study both structural plasticity in and development of the mammalian cortex. These studies aim to reveal cues to induce neuroregeneration in the damaged brain. 

Dr. Huang received his PhD in 2009 from the Universities of Ghent (UGent) and Brussels (VUB) in Belgium. As an MRC Career Development Fellow at the MRC Clinical Sciences Centre, Imperial College London, he studied structural synaptic plasticity via in vivo two-photon microscopy. In 2013, Dr. Huang joined the Heng lab at ARMI where he uses novel imaging modalities to investigate the role of proneural transcription factors in cortical neuron development.

Authors
Title
Published In
Canty A., Huang L., Jackson J., Little G., Knott G., Maco B. & De Paola V.
In vivo single neuron axotomy can induce spontaneous axon regeneration and bouton remodelling to restore pre-lesion synaptic density in specific adult cortical circuits.
Nat Commun. 2013 June 25;4:2038. doi:10.1038/ncomms3038
Allegra Mascaro A.L., Cesare P., Sacconi L., Grasselli G., Mandolesi G., Maco B., Knott G.W., Huang L., De Paola V., Strata P. & Pavone F.S.
In vivo single branch axotomy induces GAP-43 dependent sprouting and synaptic remodelling in cerebellar cortex.
Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10824-10829. doi: 10.1073/pnas.1219256110. Epub 2013 Jun 10.
Grillo F.W., Song S., Teles-Grilo Ruivo L.M., Huang L., Gao G., Knott GW, Maco B., Ferretti V., Thompson D., Little G.E. & De Paola V.
Increased axonal bouton dynamics in the aging mouse cortex.
Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1514-23. doi: 10.1073/pnas.1218731110. Epub 2013 Mar 29.