Maté is spearheading the use of complex in vitro and in vivo models for studying the cell-intrinsic actin cytoskeleton cues and dynamics that govern the invasive migration of tumour cells, the tissue scanning of T cells and their cytotoxic interaction with tumour cells. Using a multidisciplinary approach encompassing cell biology, biophysics, bioimage informatics and advanced light microscopy, he aims to unravel fundamental actin-based processes and develop new methodologies for basic cell biological research. Maté’s research relies heavily on advanced microscopy and the development of image analysis platforms capable of automatically detecting and analysing the kinetics of actomyosin, cell movement and protrusions.

Contact Maté: 

EMBL Australia node in Single Molecule Science

The University of New South Wales

Level 3, Lowy Cancer Research Centre

Sydney, NSW 2052, Australia

Phone: +61 (0) 293 858 020

Fax: +61 (0) 293 851 389

Dr. Maté Biro received his PhD at the Max Planck Institute of Molecular Cell Biology and Genetics in Germany in 2011.

His doctoral work focused on the biophysics of cellular actin cortex assembly. He previously studied Physics (BSc) and then Bioinformatics and Theoretical Systems Biology (MSc) at the Imperial College in London, UK, and did his Masters research at MIT, Cambridge, MA, USA.

He has worked at a particle accelerator in Tsukuba, Japan and as a Research Associate at the Bioinformatics Institute of the A*STAR in Singapore.

In 2012, he moved to Sydney and the Centenary Institute at the University of Sydney, where he initially worked as a postdoc and then as of 2014 as group leader of the Cellular Mechanobiology lab.

Dr. Biro joined EMBL Australia as a group leader at the Single Molecule Science node at UNSW in January 2016.

His research, highly multidisciplinary in nature, focuses on the dynamics and regulation of the actin cytoskeleton, notably during the migration of T cells and tumour cells, and the immunological interactions between them.

Curriculum vitae:

Published In

Sedzinski J., Hannezo E., Tu F., Biro M., and Wallingford J.

RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells

Journal of Cell Science 2017, 130(2): 420-428

Marshall A.D., Bailey C.G., Champ K., Vellozzi M., O’Young P., Metierre C., Feng Y., Thoeng A., Richards A.M., Schmitz U., Biro M., Jayasinghe R., Ding L., Anderson L., Mardis E.R., Rasko J.E.J.

CTCF Genetic Alterations in Endometrial Carcinoma are Pro-tumorigenic

Oncogene 2017, 36(29):4100-4110

Newman P.,  Galenano Niño J.L., Graney P., Razal J.M., Minett A.I., Ribas J., Ovalle-Robles R., Biro M.*, Zreiqat H.*

Relationship between nanotopographical alignment and stem cell fate with live imaging and shape analysis

Scientific Reports 2016, 6:37909 doi: 10.1038/srep37909

(∗ equal contribution)

Tay S.S., Carol H., and Biro M.

TriKEs and BiKEs join CARs on the cancer immunotherapy highway

Human Vaccines & Immunotherapeutics 2016, 12(11): 2790-2796

Galeano Niño J.L., Kwan R.Y.Q., Weninger W., and Biro M.

Antigen-specific T cells fully conserve antitumour function following cryopreservation

Immunology and Cell Biology 2016, 94(4): 411-418

Sedzinski J., Hannezo E., Tu F., Biro M., and Wallingford J.

Emergence of an Apical Epithelial Cell Surface In Vivo

Developmental Cell 2016, 36(1): 24-35

Biro M.* and Maître J.L.

Dual Pipette Aspiration: A Unique Tool for Studying Intercellular Adhesion

Methods in Cell Biology 2015, 125: 255-267, Biophysical Methods in Cell Biology, Vol. I, Elsevier Academic Press, Waltham, MA, USA

(* volume cover)

Newman P., Lu Z., Roohani-Estefani S.I., Church T.L., Biro M., Davies B., King A., Mackenzie K., Minett A.I. & Zreiqat H.

Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering

Journal of Materials Chemistry B 2015, 3(42): 8337-8347

Tong P.L., Roediger B., Kolesnikoff N., Biro M., Tay S.S., Jain R., Shaw L.E., Grimbaldeston M.A., Weninger W.

The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by in vivo microscopy

Munoz M.A.*, Biro M.*, Weninger W. 

T cell migration in intact lymph nodes in vivo

Current Opinion in Cell Biology 2014, 30: 17-24

(* equal contribution)

Biro M.*, Munoz M.A., Weninger W.

Targeting Rho-GTPases in immune cell migration and inflammation

British Journal of Pharmacology 2014, 171(24): 5491-5506

(*corresponding author)

Weninger W., Biro M., Jain R.

Leukocyte migration in the interstitial space of non-lymphoid organs

Nature Reviews Immunology 2014, 14(4): 232-246

Bovellan M., Romeo Y., Biro M., Fritzsche M., Boden A., Moulding D., Thorogate R., Jégou A., Thrasher A.J., Romet-Lemonne G., Paluch E., Roux P.P., and Charras G.

Cellular control of cortical actin nucleation

Current Biology 2014, 24(14): 1628-1635

Biro M., Romeo Y., Kroschwald S., Bovellan M., Boden A., Tcherkezian J., Roux P.P., Charras G. & Paluch E.

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging

Cytoskeleton 2013, 70(11): 741-754

Sedzinski J.*, Biro M.*, Oswald A., Tinevez J.-Y., Salbreux G. & Paluch E.

Polar actomyosin contractility destabilizes the position of the cytokinetic furrow

Nature 2011, 476(7361): 462-6

(∗ equal contribution)

Puah W.C., Cheok L.P., Biro M., Ng W.T., Wasser M.

TLM-Converter: reorganization of long time-lapse microscopy datasets for downstream image analysis

BioTechniques 2011, 51(1): 49-54