Maté is spearheading the use of complex in vitro and in vivo models for studying the cell-intrinsic actin cytoskeleton cues and dynamics that govern the invasive migration of tumour cells, the tissue scanning of T cells and their cytotoxic interaction with tumour cells. Using a multidisciplinary approach encompassing cell biology, biophysics, bioimage informatics and advanced light microscopy, he aims to unravel fundamental actin-based processes and develop new methodologies for basic cell biological research. Maté’s research relies heavily on advanced microscopy and the development of image analysis platforms capable of automatically detecting and analysing the kinetics of actomyosin, cell movement and protrusions.

Contact Maté: 

EMBL Australia node in Single Molecule Science

The University of New South Wales

Level 3, Lowy Cancer Research Centre

Sydney, NSW 2052, Australia

Phone: +61 (0) 293 858 020

Fax: +61 (0) 293 851 389

Dr. Maté Biro received his PhD at the Max Planck Institute of Molecular Cell Biology and Genetics in Germany in 2011.

His doctoral work focused on the biophysics of cellular actin cortex assembly. He previously studied Physics (BSc) and then Bioinformatics and Theoretical Systems Biology (MSc) at the Imperial College in London, UK, and did his Masters research at MIT, Cambridge, MA, USA.

He has worked at a particle accelerator in Tsukuba, Japan and as a Research Associate at the Bioinformatics Institute of the A*STAR in Singapore.

In 2012, he moved to Sydney and the Centenary Institute at the University of Sydney, where he initially worked as a postdoc and then as of 2014 as group leader of the Cellular Mechanobiology lab.

Dr. Biro joined EMBL Australia as a group leader at the Single Molecule Science node at UNSW in January 2016.

His research, highly multidisciplinary in nature, focuses on the dynamics and regulation of the actin cytoskeleton, notably during the migration of T cells and tumour cells, and the immunological interactions between them.

Authors
Title
Published In

Tay SS, Carol H, Biro M.

TriKEs and BiKEs join CARs on the cancer immunotherapy highway.

Hum Vaccin Immunother. 2016 Jun 20:1-7. [Epub ahead of print]

Galeano Niño JL, Kwan RY, Weninger W, Biro M.

Antigen-specific T cells fully conserve antitumour function following cryopreservation.

Immunol Cell Biol. 2016 Jan 12. doi: 10.1038/icb.2015.105. [Epub ahead of print]

Sedzinski J, Hannezo E, Tu F, Biro M, Wallingford JB.

Emergence of an Apical Epithelial Cell Surface In Vivo.

Dev Cell 2016 Jan 11;36(1):24-35. doi: http://dx.doi.org/10.1016/j.devcel.2015.12.013

Tong PL, Roediger B, Kolesnikoff N, Biro M, Tay SS, Jain R, Shaw LE, Grimbaldeston MA, Weninger W.

The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by in vivo microscopy

J Invest Dermatol. 2015 Jan;135(1):84-93. doi: 10.1038/jid.2014.289. Epub 2014 Aug 9.

Biro M, Maître JL.

Dual pipette aspiration: a unique tool for studying intercellular adhesion.

Methods Cell Biol. 2015;125:255-67. doi: 10.1016/bs.mcb.2014.10.007. Epub 2015 Jan 8.

Biro M, Munoz MA, Weninger W.

Targeting Rho-GTPases in immune cell migration and inflammation.

Br J Pharmacol. 2014 Dec;171(24):5491-506. doi: 10.1111/bph.12658. Epub 2014 Jul 2.

Munoz MA, Biro M, Weninger W.

T cell migration in intact lymph nodes in vivo.

Curr Opin Cell Biol. 2014 Oct;30:17-24. doi: 10.1016/j.ceb.2014.05.002. Epub 2014 Jun 5.

Bovellan M, Romeo Y, Biro M, Fritzsche M, Boden A, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Paluch E, Roux PP, Charras G.

Cellular control of cortical actin nucleation.

Curr Biol. 2014 Jul 21;24(14):1628-35. doi: 10.1016/j.cub.2014.05.069. Epub 2014 Jul 10.

Weninger W, Biro M, Jain R.

Leukocyte migration in the interstitial space of non-lymphoid organs.

Nature Reviews Immunology. 2014;14(4): 232-246. doi:10.1038/nri3641. Epub 07 March 2014

Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch E.

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

Cytoskeleton (Hoboken). 2013 Nov;70(11):741-54. doi: 10.1002/cm.21142. Epub 2013 Oct 17.

Sedzinski J*, Biro M*, Oswald A, Tinevez JY, Salbreux G, Paluch E. (* equal contribution)

Polar actomyosin contractility destabilizes the position of the cytokinetic furrow.

Nature. 2011 Aug 7;476(7361):462-6. doi: 10.1038/nature10286.