The Biro group are primarily concerned with the cell biology and mechanics of the actin cytoskeleton, and how immune cells (T cells) locate and kill cancer cells.

The group uses high-speed imaging to watch how T cells, and the cancer cells they target, move throughout complex 3-dimensional environments.

They also use single-molecule microscopes to observe the dynamics of actin, which is a major component of the cytoskeleton.

Biro group

From left to right: Feyza Colakoglu (research assistant), Maté Biro (group leader), Jorge Luis Galeano Niño (PhD student), Daryan Kempe (postdoc), Manuela Ecker (PhD student, Rossy lab), Matt Govendir (PhD student), Natasha Kaushik (research assistant, Rossy lab), Jacqueline Tearle (PhD student), Sophie Pageon (postdoc), Gregory Redpath (postdoc, Rossy lab), Haig Vartoukian (Honours student, Rossy lab), Jérémie Rossy (visiting group leader).

  • How T cell’s cytoskeleton drives the scanning for and interactions with tumour cells once located in the body
  • Migration of T cells through the body
  • See and quantitate the intricate dynamics and interactions of actin
Published In

Zenker J., et al. (2018)

in press

Cell  in press  (* senior & corresponding author) 

Chou J., Poole K., Biro M. (2017)

Your body’s cells use and resist force, and they move. It’s mechanobiology.

The Conversation October 20, 2017

Sedzinski J., Hannezo E., Tu F., Biro M., and Wallingford J. (2017)

RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells

Journal of Cell Science 130(2): 420-428 

Marshall A.D., Bailey C.G., Champ K., Vellozzi M., O’Young P., Metierre C., Feng Y., Thoeng A., Richards A.M., Schmitz U., Biro M., Jayasinghe R., Ding L., Anderson L., Mardis E.R., Rasko J.E.J. (2017)

CTCF Genetic Alterations in Endometrial Carcinoma are Pro-tumorigenic 

Oncogene 36(29):4100-4110

Newman P., Galenano Niño J.L., Graney P., Razal J.M., Minett A.I., Ribas J., Ovalle-Robles R., Biro M.*, Zreiqat H.* (2016)

Relationship between nanotopographical alignment and stem cell fate with live imaging and shape analysis 

Scientific Reports 6:37909 doi: 10.1038/srep37909 (*senior and corresponding authors)

Tay SS, Carol H, Biro M. (2016)

TriKEs and BiKEs join CARs on the cancer immunotherapy highway.

Hum Vaccin Immunother. 2016 12(11):2790-2796

Galeano Niño JL, Kwan RY, Weninger W, Biro M. (2016)

Antigen-specific T cells fully conserve antitumour function following cryopreservation.

Immunol Cell Biol. 2016 doi: 10.1038/icb.2015.105

Sedzinski J, Hannezo E, Tu F, Biro M, Wallingford JB. (2016)

Emergence of an apical epithelial cell surface In vivo.

Dev. Cell 2016 36(1):24-35

Newman P, Lu Z, Roohani-Esfahani SI, Church TL, Biro M, Davies B, King A, Mackenzie K, Minett AI, Zreiqat H. (2015)

Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering.

J Mater Chem. B 2015 3:8337-8347

Tong PL, Roediger B, Kolesnikoff N, Biro M, Tay SS, Jain R, Shaw LE, Grimbaldeston MA, Weninger W. (2015)

The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by in vivo microscopy

J Invest Dermatol. 2015  135(1):84-93

Biro M, Maître JL. (2015)

Dual pipette aspiration: a unique tool for studying intercellular adhesion.

Methods Cell Biol. 2015 125:255-67

Biro M*, Munoz MA, Weninger W. (2014)

Targeting Rho-GTPases in immune cell migration and inflammation.

Br J Pharmacol. 2014  171(24):5491-506 (*corresponding author)

Munoz MA*, Biro M*, Weninger W. (2014)

T cell migration in intact lymph nodes in vivo.

Curr Opin Cell Biol. 2014 30:17-24 (*equal contribution)

Weninger W, Biro M, Jain R. (2014)

Leukocyte migration in the interstitial space of non-lymphoid organs.

Nature Reviews Immunology. 2014 14(4): 232-246

Bovellan M, Romeo Y, Biro M, Fritzsche M, Boden A, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Paluch E, Roux PP, Charras G. (2014)

Cellular control of cortical actin nucleation.

Curr Biol. 2014 24(14):1628-35

Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch E. (2013)

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

Cytoskeleton 2013 70(11):741-54

Sedzinski J*, Biro M*, Oswald A, Tinevez JY, Salbreux G, Paluch E. (2011)

Polar actomyosin contractility destabilizes the position of the cytokinetic furrow.

Nature 2011 476(7361):462-6 (* equal contribution)

Puah W.C., Cheok L.P., Biro M., Ng W.T., Wasser M. (2011)

TLM-Converter: reorganization of long time-lapse microscopy datasets for downstream image analysis

BioTechniques 51(1): 49-54