The Biro group are primarily concerned with the cell biology and mechanics of the actin cytoskeleton, and how immune cells (T cells) locate and kill cancer cells.

The group uses high-speed imaging to watch how T cells, and the cancer cells they target, move throughout complex 3-dimensional environments.

They also use single-molecule microscopes to observe the dynamics of actin, which is a major component of the cytoskeleton.

Biro group

From left to right: Feyza Colakoglu (research assistant), Maté Biro (group leader), Jorge Luis Galeano Niño (PhD student), Daryan Kempe (postdoc), Manuela Ecker (PhD student, Rossy lab), Matt Govendir (PhD student), Natasha Kaushik (research assistant, Rossy lab), Jacqueline Tearle (PhD student), Sophie Pageon (postdoc), Gregory Redpath (postdoc, Rossy lab), Haig Vartoukian (Honours student, Rossy lab), Jérémie Rossy (visiting group leader).

  • How T cell’s cytoskeleton drives the scanning for and interactions with tumour cells once located in the body
  • Migration of T cells through the body
  • See and quantitate the intricate dynamics and interactions of actin
Authors
Title
Published In

Zenker J., White M.D., Gasnier M., Alvarez Y.D., Lim H.Y.G., Bissiere S., Biro M.*, Plachta N.* (2018)

Expanding Actin Rings Zipper the Mouse Embryo for Blastocyst Formation

Cell 173(3):776-791.e17 

(*senior and corresponding author) 

Chou J., Poole K., Biro M. (2017)

Your body’s cells use and resist force, and they move. It’s mechanobiology.

The Conversation October 20, 2017

Sedzinski J., Hannezo E., Tu F., Biro M., and Wallingford J. (2017)

RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells

Journal of Cell Science 130(2): 420-428

Marshall A.D., Bailey C.G., Champ K., Vellozzi M., O’Young P., Metierre C., Feng Y., Thoeng A., Richards A.M., Schmitz U., Biro M., Jayasinghe R., Ding L., Anderson L., Mardis E.R., Rasko J.E.J. (2017)

CTCF Genetic Alterations in Endometrial Carcinoma are Pro-tumorigenic 

Oncogene 36(29):4100-4110

Newman P., Galenano Niño J.L., Graney P., Razal J.M., Minett A.I., Ribas J., Ovalle-Robles R., Biro M.*, Zreiqat H.* (2016)

Relationship between nanotopographical alignment and stem cell fate with live imaging and shape analysis 

Scientific Reports 6:37909 doi: 10.1038/srep37909 

(*senior and corresponding author)

Tay SS, Carol H, Biro M. (2016)

TriKEs and BiKEs join CARs on the cancer immunotherapy highway.

Galeano Niño JL, Kwan RY, Weninger W, Biro M. (2016)

Antigen-specific T cells fully conserve antitumour function following cryopreservation.

Immunology and Cell Biology 94(4): 411-418 

Sedzinski J, Hannezo E, Tu F, Biro M, Wallingford JB. (2016)

Emergence of an apical epithelial cell surface In vivo.

Developmental Cell 36(1):24-35

Newman P, Lu Z, Roohani-Esfahani SI, Church TL, Biro M, Davies B, King A, Mackenzie K, Minett AI, Zreiqat H. (2015)

Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering.

Tong PL, Roediger B, Kolesnikoff N, Biro M, Tay SS, Jain R, Shaw LE, Grimbaldeston MA, Weninger W. (2015)

The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by in vivo microscopy

Biro M, Maître JL. (2015)

Dual pipette aspiration: a unique tool for studying intercellular adhesion.

Munoz MA*, Biro M*, Weninger W. (2014)

T cell migration in intact lymph nodes in vivo.

Current Opinion in Cell Biology 30:17-24 

(*equal contribution)

Biro M*, Munoz MA, Weninger W. (2014)

Targeting Rho-GTPases in immune cell migration and inflammation.

British Journal of Pharmacology 171(24):5491-5506

(*corresponding author)

Weninger W, Biro M, Jain R. (2014)

Leukocyte migration in the interstitial space of non-lymphoid organs.

Bovellan M, Romeo Y, Biro M, Fritzsche M, Boden A, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Paluch E, Roux PP, Charras G. (2014)

Cellular control of cortical actin nucleation.

Current Biology 24(14):1628-1635

Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch E. (2013)

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

Cytoskeleton 70(11):741-754

Sedzinski J*, Biro M*, Oswald A, Tinevez JY, Salbreux G, Paluch E. (2011)

Polar actomyosin contractility destabilizes the position of the cytokinetic furrow.

Nature 476(7361):462-466 

(*equal contribution)

Puah W.C., Cheok L.P., Biro M., Ng W.T., Wasser M. (2011)

TLM-Converter: reorganization of long time-lapse microscopy datasets for downstream image analysis

BioTechniques 51(1): 49-54