Contact Details

Maté is spearheading the use of complex in vitro and in vivo models for studying the cell-intrinsic actin cytoskeleton cues and dynamics that govern the invasive migration of tumour cells, the tissue scanning of T cells and their cytotoxic interaction with tumour cells. Using a multidisciplinary approach encompassing cell biology, biophysics, bioimage informatics and advanced light microscopy, he aims to unravel fundamental actin-based processes and develop new methodologies for basic cell biological research. Maté’s research relies heavily on advanced microscopy and the development of image analysis platforms capable of automatically detecting and analysing the kinetics of actomyosin, cell movement and protrusions.

Contact Maté: 

EMBL Australia node in Single Molecule Science

The University of New South Wales

Level 3, Lowy Cancer Research Centre

Sydney, NSW 2052, Australia

Phone: +61 (0) 293 858 020

Fax: +61 (0) 293 851 389

Dr. Maté Biro received his PhD at the Max Planck Institute of Molecular Cell Biology and Genetics in Germany in 2011.

His doctoral work focused on the biophysics of cellular actin cortex assembly. He previously studied Physics (BSc) and then Bioinformatics and Theoretical Systems Biology (MSc) at the Imperial College in London, UK, and did his Masters research at MIT, Cambridge, MA, USA.

He has worked at a particle accelerator in Tsukuba, Japan and as a Research Associate at the Bioinformatics Institute of the A*STAR in Singapore.

In 2012, he moved to Sydney and the Centenary Institute at the University of Sydney, where he initially worked as a postdoc and then as of 2014 as group leader of the Cellular Mechanobiology lab.

Dr. Biro joined EMBL Australia as a group leader at the Single Molecule Science node at UNSW in January 2016.

His research, highly multidisciplinary in nature, focuses on the dynamics and regulation of the actin cytoskeleton, notably during the migration of T cells and tumour cells, and the immunological interactions between them.

Curriculum vitae

Highlight publications

Authors
Title
Published In

Galeano Niño J.L, Pageon S.V., Tay S.S., Colakoglu F., Kempe D., Hywood J., Mazalo J.K., Cremasco J., Govendir M.A., Dagley L.F., Hsu K., Rizzetto S., Zieba J., Rice G., Prior V., O’Neill G.M., Williams R.J., Nisbet D.R., Kramer B., Webb A.I., Luciani F., Read M.N., Biro M. (2020)

Cytotoxic T Cells Swarm by Homotypic Chemokine Signalling

eLife (In press)

Lim H.Y.G., Alvarez Y.D., Gasnier M., WangY., Tetlak P., Bissiere S., Wang H., Biro M., Plachta N. (2020)

Keratins are asymmetrically inherited fate determinants in the mammalian embryo

Nature  585(7825):404-409

Piper A-K., Sophocleous R., Ross S., Evesson F., Saleh O., Bournazos A.,  Yasa J., Reed C., Woolger N., Sluyter R., Greer P., Biro M., Lemckert F., Cooper S. (2020)

Loss of calpains-1 and -2 prevents repair of plasma membrane scrape injuries, but not small pores, and induces a severe muscular dystrophy

American Journal of Physiology 318(6):C1226-C1237

Patkunarajah A., Stear J.H.,Moroni M., Schroeter L., Blaszkiewicz J., Tearle J.L.E., Cox C.D., Fuerst C., Sanchez-Carranza O., del Angel Ocana Fernandez M., Fleischer R., Eravci M., Weise C., Martinac B., Biro M., Lewin G.R, Poole K. (2020)

TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration

eLife e53308

Galeano Niño J.L.*, Tay S.S*., Tearle J.L.E.*, Xie J., Govendir M.A., Kempe D., Mazalo J., Drew A.P., Colakoglu F., Kummerfeld S.K., Proud C.G., Biro M. (2020)

The Lifeact-EGFP mouse is a translationally controlled fluorescent reporter of T cell activation

Journal of Cell Science 133(5): jcs238014

Obeidy, P., Lining, J., Oehlers, S., Zulkhernain, N., Lee, Q., Galeano Niño, J., Kwan, R., Tikoo, S., Cavanagh, L., Mrass, P., Cook, A., Jackson, S., Biro, M., Roediger, B., Sixt, M., Weninger, W. (2019)

Partial loss of actin nucleator Actin Related Protein 2/3 activity triggers blebbing in primary T lymphocytes

Immunology and Cell Biology 98(2):93-113

Redpath G.M.I., Ecker M., Kapoor-Kaushik N., Vartoukian H., Carnell M., Kempe D., Biro M., Ariotti N., Rossy J. (2019)

Flotillins promote T cell receptor sorting through a fast Rab5-Rab11 endocytic recycling axis

Nature Communications 10(1):4392

Meiring J., Bryce N., Galeano Niño J.L., Gabriel A., Tay S.S., Hardeman E., Biro M., Gunning P. (2019)

Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments

Scientific Reports 9(1):6504

Mitchell C.B., Black B., Sun F., Chrzanowski W., Cooper-White J., Maisonneuve B., Stringer B., Day B., Biro M., O’Neill G.M. (2018)

Tropomyosin Tpm 2.1 loss induces glioblastoma spreading in soft brain-like environments

Journal of Neuro-Oncology 141(2):303-313

Moran I., Nguyen A., Khoo W.H., Butt D., Bourne K., Young C., Hermes J.R., Biro M., Gracie G., Ma C.S., Munier C.M.L., Luciani F., Zaunders J., Parker A., Kelleher A.D., Tangye S.G., Croucher P.I., Brink R., Read M.N., Phan T.G. (2018)

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

Nature Communications 9(1):3372

Pageon S.V., Govendir M.A., Kempe D., Biro M. (2018)

Mechanoimmunology: molecular-scale forces govern immune cell functions

Molecular Biology of the Cell 29(16):1919-1926

Zenker J., White M.D., Gasnier M., Alvarez Y.D., Lim H.Y.G., Bissiere S., Biro M.*, Plachta N.* (2018)

(*senior & corresponding author) 

Expanding Actin Rings Zipper the Mouse Embryo for Blastocyst Formation

Cell 173(3):776-791.e17

Chou J., Poole K., Biro M. (2017)

Your body’s cells use and resist force, and they move. It’s mechanobiology.

The Conversation October 20, 2017

Sedzinski J., Hannezo E., Tu F., Biro M., and Wallingford J. (2017)

RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells

The Journal of Cell Science 130(2): 420-428

Marshall A.D., Bailey C.G., Champ K., Vellozzi M., O’Young P., Metierre C., Feng Y., Thoeng A., Richards A.M., Schmitz U., Biro M., Jayasinghe R., Ding L., Anderson L., Mardis E.R., Rasko J.E.J. (2017)

CTCF Genetic Alterations in Endometrial Carcinoma are Pro-tumorigenic

Oncogene 36(29):4100-4110

Newman P.,  Galenano Niño J.L., Graney P., Razal J.M., Minett A.I., Ribas J., Ovalle-Robles R., Biro M.*, Zreiqat H.* (2016)

(*senior and corresponding author)

Relationship between nanotopographical alignment and stem cell fate with live imaging and shape analysis

Scientific Reports 6:37909 doi: 10.1038/srep37909

Tay S.S., Carol H., and Biro M. (2016)

TriKEs and BiKEs join CARs on the cancer immunotherapy highway

Human Vaccines & Immunotherapeutics 12(11): 2790-2796

Galeano Niño J.L., Kwan R.Y.Q., Weninger W., and Biro M. (2016)

Antigen-specific T cells fully conserve antitumour function following cryopreservation

Immunology and Cell Biology 94(4): 411-418

Sedzinski J., Hannezo E., Tu F., Biro M., and Wallingford J. (2016)

Emergence of an Apical Epithelial Cell Surface In Vivo

Developmental Cell 36(1): 24-35

Biro M. and Maître J.L. (2015)

Dual Pipette Aspiration: A Unique Tool for Studying Intercellular Adhesion

Methods in Cell Biology 125: 255-267, Biophysical Methods in Cell Biology, Vol. I, Elsevier Academic Press, Waltham, MA, USA

Newman P., Lu Z., Roohani-Estefani S.I., Church T.L., Biro M., Davies B., King A., Mackenzie K., Minett A.I. & Zreiqat H. (2015)

Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering

Journal of Material Chemistry B 3(42): 8337-8347

Tong P.L., Roediger B., Kolesnikoff N., Biro M., Tay S.S., Jain R., Shaw L.E., Grimbaldeston M.A., Weninger W. (2015)

The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by in vivo microscopy

Journal of Investigative Dermatology 135(1): 84-93

Munoz M.A.*, Biro M.*, Weninger W. (2014)

(*equal contribution)

T cell migration in intact lymph nodes in vivo

Current Opinion in Cell Biology 2014, 30: 17-24

Biro M.*, Munoz M.A., Weninger W. (2014)

(*corresponding author)

Targeting Rho-GTPases in immune cell migration and inflammation

British Journal of Pharmacology 171(24): 5491-5506

Weninger W., Biro M., Jain R. (2014)

Leukocyte migration in the interstitial space of non-lymphoid organs

Nature Reviews Immunology 14(4): 232-246

Bovellan M., Romeo Y., Biro M., Fritzsche M., Boden A., Moulding D., Thorogate R., Jégou A., Thrasher A.J., Romet-Lemonne G., Paluch E., Roux P.P., and Charras G. (2014)

Cellular control of cortical actin nucleation

Current Biology 24(14): 1628-1635

Biro M., Romeo Y., Kroschwald S., Bovellan M., Boden A., Tcherkezian J., Roux P.P., Charras G. & Paluch E. (2013)

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging

Cytoskeleton 70(11): 741-754

Sedzinski J.*, Biro M.*, Oswald A., Tinevez J.-Y., Salbreux G. & Paluch E. (2011)

(*equal contribution)

Polar actomyosin contractility destabilizes the position of the cytokinetic furrow

Nature 476(7361): 462-6

Puah W.C., Cheok L.P., Biro M., Ng W.T., Wasser M. (2011)

TLM-Converter: reorganization of long time-lapse microscopy datasets for downstream image analysis

BioTechniques 51(1): 49-54

 
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