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Sophie is interested in the strategies that immune cells, in particular T cells and Natural Killer cells, use in order to hunt down and efficiently destroy cancer cells. She employs a combination of super-resolution microscopy, live cell imaging and flow cytometry techniques to decipher the molecular mechanisms underlying the migratory behaviour of immune cells and their decision to kill or not to kill a target cell they encounter. She is currently investigating the molecular cues that direct T cell migration in a tumour microenvironment.

Dr. Sophie Pageon is a biologist working at the interface between immunology and advanced microscopy, aiming to gain a deeper understanding of the mechanisms regulating immune cell functions.

Sophie received her PhD from Imperial College London, UK, in 2012. Her doctoral work focused on the recognition of cancer cells by Natural Killer (NK) cells using advanced fluorescence microscopy techniques including single-molecule localisation microscopy. She previously studied Biology (BSc) at Imperial College London, with an exchange year at the University of Heidelberg, Germany, and did her Masters in Biochemical Research (MRes) also at Imperial College London.

In 2013, she moved to Sydney to the University of New South Wales, where she worked as a postdoctoral researcher investigating the molecular mechanisms underlying the triggering of T cell signalling upon recognition of an antigen.

In January 2017, she joined the Cell Motility and Mechanobiology group within the Single Molecule Science node at UNSW, where she is working on an exciting project investigating the recruitment of T cells to tumours using advanced 3D imaging techniques.