Understanding the organisational principles of endosomal trafficking

A living cell is an active and dynamic system, where all the non-living constituents of a cell organise themselves through a complex set of interactions.

There are millions of interactions going on between tens of thousands of components. One central component of cellular life is vesicular trafficking on the cytoskeleton networks inside the cells. Quite analogous to how a city is organised (with general public transport systems consisting of buses, light rails, and trains, specific highways for long-distance transport, cars, motorbikes etcetera), the inside of the cells have self-assembled, polymerised proteins building up the tracks, membrane vesicles that carry specific cargoes building up the transport carriers, and the motor proteins that generate the force to pull the membrane vesicles to move along the tracks building up the transport system.  

The Arumugam Group aims to understand the organisational principles of this transport system, as well as understand their role in orchestrating fundamental processes governing multicellular life, such as patterning during development.

Understanding how complex properties arise out of molecules and their interactions, with a primary focus on endosomal trafficking at the level of single cells and in the context of intercellular communications in development.

  • Cell biology and developmental biology
  • Advanced fluorescence imaging, optogenetics, image and data analysis
  • Self-organisation, and pattern formation

Highlight publications

Authors
Title
Published In

York HM, Kaur A, Patil A, Bhowmik A, Moorthi UK, Hyde GJ, Gandhi H, Gaus K, Arumugam S.

bioRxiv 481796.

Pezeshkian W*, Gao H*, Arumugam S*, Becken U, Bassereau P, Florent JC, Ipsen JH, Johannes L, Shillcock JC.

*Equal first authors

ACS Nano. (2017) Jan 24;11(1):314-324.

Arumugam S, Petrov EP and Schwille P.

Biophysical Journal. (2015) 108 (5), 1104-1113.

Arumugam S, Petrasek Z and Schwille P.

PNAS (2014) April 1: 111 (13), E1192-E1200.