Investigating protein networks and mechanisms that regulate protein trafficking, signalling and organelle function

The Apaja Group is investigating the protein networks and molecular mechanisms that regulate membrane trafficking and proteostasis in human cells.

An important aspect is to gain a molecular-level understanding of how cellular stress responses change membrane organelle function, protein degradation, pH and calcium regulation and signalling events including ubiquitin signalling.

The combined dynamics regulate proteostasis and is monitored by protein quality control machinery.

  • Ubiquitin signalling and dynamics in proteostasis regulation and membrane trafficking in human disease.
  • Protein networks that regulate cargo sorting especially at the lysosome-autophagy pathway.
  • Functional interaction networks modulating proteostasis by cellular stress responses; organelle proteomics and effect of pH and calcium regulation.

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Authors
Title
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Kazan JM, Lukacs GL, Apaja PM, Pause A.

Methods in Molecular Biology (2019) 1998:93-103.

Okiyoneda T, Veit G, Sakai R, Aki M, Fujihara T, Higashi M, Susuki-Miyata S, Miyata M, Fukuda N, Yoshida A, Xu H, Apaja PM, Lukacs GL.

Developmental Cell (2018) 44(6):694-708.

Gaitán-Peñas H, Apaja PM, Arnedo T, Castellanos A, Elorza‐Vidal X, Soto D, Gasull X, Lukacs GL, Estévez R.

The Journal of Physiology (2017) 595(22):6993-7008.

Kharitidi D, Apaja PM, Manteghi S, Suzuki K, Malitskaya E, Roldan A, Gingras MC, Takagi J, Lukacs GL, Pause A.

Cell Reports (2015) 13(3):599-609.

Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL.

Science Translational Medicine (2014) 6(246). 

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A full list of Pirjo Apaja’s publications can be viewed on ORCID.