Understanding the regulation of the immune system from a
systems-level perspective
The Lynn group is a multi-disciplinary group that is equally divided between computational systems biology and experimental immunology.
On the wet-lab side, the group employs in vitro and in vivo experimental and clinical models, coupled with systems biology approaches, to investigate the interplay between the microbiome, vaccines and the immune system. On the bioinformatics side, Lynn's group leads the development of InnateDB, an internationally recognised systems biology platform for innate immunity networks.
David Lynn also leads the computational biology aspects of a €12 million European Commission-funded project called PRIMES, which is investigating how to model, and subsequently therapeutically target, protein interaction networks in cancer.
Current research:
The Lynn Group is continuing their work investigating the role that the microbiota in early-life plays in shaping the developing immune system, and how this influences responses to vaccination. To do this, they will continue to employ mouse models (including germ-free) and run a large clinical study in human infants.
On the bioinformatics side of the group, they recently developed a novel application for spatial transcriptomics and will continue to develop novel software to facilitate systems-level analysis.
